Sodium as a Mediator of Non-Phorbol Tumor Promoter Action
نویسندگان
چکیده
منابع مشابه
Epigenetics of Phorbol Esters, a Tumor Promoter and Differentiation Inducer
Epigenetics is the study of structurally and functionally relevant molecular changes to the genome that do not constitute a change in the nucleotide sequence such as DNA methylation and histone modifications. These changes are involved in the expression and repression of different genes in a particular cell type. Phorbol esters are diterpene compound known as phorbol 12-myristate 13-acetate (PM...
متن کاملCalcium as a Mediator of Hormone Action
activities and by electron microscopy. The higher-density fractions (1.2-1.5~-sucrose) contained actomyosin fibrils, mitochondria and sacroplasmic reticulum, and were enriched in cytochrome oxidase and Caz+-dependent adenosine triphosphatase. The endoplasmic-reticulum marker, NADPH-cytochtome c reductase, was found throughout the gradient. Lower-density fractions (0.75-1 .OM sucrose) were enric...
متن کاملOkadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.
Okadaic acid is a polyether compound of a C38 fatty acid, isolated from a black sponge, Halichondria okadai. Previous studies showed that okadaic acid is a skin irritant and induces ornithine decarboxylase (OrnDCase; 3-hydroxyl-L-glutamate 1-carboxy-lyase, EC 4.1.1.17) in mouse skin 4 hr after its application to the skin. This induction was strongly inhibited by pretreatment of the skin with 13...
متن کاملThe Tumor-promoter Phorbol Ester (12-0-tetradecanoyl-phorbol-13-acetate), a Potent Aggregating Agent for Blood Platelets
The phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumor-promoting agent, caused irreversible platelet aggregation when more than 0.02 microM was stirred with human citrated or heparinized platelet-rich plasma (PRP). With washed platelets, 1 nM was effective. The alcohol phorbol, which has little tumor-promoting activity, failed to cause platelet aggregation. With all but low con...
متن کاملThe leukemogenic action of phorbol.
The unesterified, water-soluble compound phorbol, which does not act as a promoting agent for skin carcinogenesis when applied topically (although phorbol esters extracted from croton seed oil display pronounced activity), was tested in female SWR mice for promoting action by the systemic route, in the hope of overcoming a suspected solubility barrier in the skin. The results were negative. A h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63749-4